Research progress of ubiquitination and deubiquitination in tumor immune regulation
10.3969/j.issn.1000-484X.2024.11.032
- VernacularTitle:泛素化与去泛素化修饰在肿瘤免疫调控中的研究进展
- Author:
Xue ZHANG
1
;
Wengui SHI
;
Zuoyi JIAO
Author Information
1. 兰州大学第二医院普外科,兰州 730030
- Keywords:
Ubiquitination;
Deubiquitination;
Tumor immunity;
Immune checkpoint
- From:
Chinese Journal of Immunology
2024;40(11):2427-2433
- CountryChina
- Language:Chinese
-
Abstract:
Ubiquitination is an important post-translational modification of proteins,which plays an important regulatory role in pathological processes such as cancer and immune diseases.Ubiquitination and deubiquitination are not only involved in the process of activation,proliferation and differentiation of immune cells,but also can regulate immune checkpoints and change the response rate of tumor to immunotherapy.Based on this,targeting the process of ubiquitination and deubiquitination can improve the inhibitory tumor microenvironment,increase the activity and infiltration number of immune cells,and downregulate immune checkpoints,which can enhance the anti-tumor effect when further combined with immune checkpoint inhibitors and chemotherapy drugs.Therefore,this review focuses on the roles of ubiquitination and deubiquitination enzymes in tumor-infiltrating immune cells and immune check-points,and summarizes the latest discoveries and applications of their small molecule inhibitors in tumor therapy.It provides a new idea to target the immune microenvironment by ubiquitination and deubiquitination,and improve the responsiveness of tumors to immunotherapy.
