Research progress of pyroptosis in tumor immunity
10.3969/j.issn.1000-484X.2024.11.031
- VernacularTitle:细胞焦亡在肿瘤免疫中的研究进展
- Author:
Yuting HAN
1
;
Dongdong LI
;
Peimin LIU
Author Information
1. 河南中医药大学第二附属医院肿瘤科,郑州 450002
- Keywords:
Pyroptosis;
Immunotherapy;
Inflammatory cytokines;
Gasdermin family;
Inflammasomes
- From:
Chinese Journal of Immunology
2024;40(11):2421-2426
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis,as the main mechanism of host defense,is the key link between innate immunity and adaptive immunity.Pyroptosis is accompanied by membrane rupture,and the cells release a large number of inflammatory mediators,which recruit inflam-matory cells and activate the inflammatory response.Tumor immunotherapy utilizes the natural defense mechanism of the host to ad-minister certain immunomodulators,antibodies or stimulation-adjusted immune cells to obtain stronger anti-tumor effects.Recent stud-ies have shown that pyroptosis has a positive regulatory effect on tumor immunotherapy,including immune checkpoint inhibitors and chimeric antigen receptor T-cell immunotherapy,etc.In this paper,based on the published experimental studies,the mechanism of pyroptosis and its correlation with tumor immunotherapy.In this paper,based on the published experimental studies,the mechanism of cellular apoptosis in tumor immunity is elucidated on the basis of the mechanism of apoptosis and the correlation between tumor im-munotherapy,in order to provide new ideas for the basic and clinical research of malignant tumors.
