Latest research progress in lymphocyte-targeted treatment of systemic lupus erythematosus
10.3969/j.issn.1000-484X.2024.10.037
- VernacularTitle:靶向淋巴细胞治疗系统性红斑狼疮的研究进展
- Author:
Yue HUANG
1
;
Jinhui HONG
;
Suibi YANG
;
Xinyi JIANG
;
Yuqing GONG
;
Jing WU
Author Information
1. 杭州师范大学基础医学院,杭州 310000
- Keywords:
Systemic lupus erythematosus;
B cells;
T cells;
Pathogenesis;
Monoclonal autoantibody
- From:
Chinese Journal of Immunology
2024;40(10):2236-2240,封3-封4
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus(SLE)is an autoimmune disease with high heterogeneity in tissues and organs,Whose pathogenesis is still unclear.Lymphocytes are important immune cells involved in the occurrence and development of SLE.It has been found that the abnormal activation of T cells and B cells are important causes of SLE.In this review,by summarizing the role of T cells and B cells in the pathogenesis of SLE and the latest research progress in lymphocyte-targeted treatment strategy of SLE,the important scientific evidences can be provided to the study of the pathogenesis of SLE and the development of new medicines for the treatment of SLE.
