Research progress of autophagy in pancreatic inflammation and fibrosis
10.3969/j.issn.1000-484X.2024.10.036
- VernacularTitle:细胞自噬在胰腺炎症及纤维化中的研究进展
- Author:
He GAO
1
;
Xiaofan XU
;
Lifang DUAN
;
Hong ZHANG
Author Information
1. 陕西中医药大学,咸阳 712046
- Keywords:
Chronic pancreatitis;
Pancreatic fibrosis;
Autophagy;
Acinar cells;
Pancreatic stellate cell;
Macrophage
- From:
Chinese Journal of Immunology
2024;40(10):2229-2235
- CountryChina
- Language:Chinese
-
Abstract:
Chronic pancreatitis(CP)is a progressive fibroinflammatory disease characterized by destruction of pancreatic aci-nar cells,infiltration of inflammatory cells,activation of pancreatic stellate cell(PSC),and pancreatic fibrosis.Autophagy partici-pates in the maintenance of cell homeostasis.Recent studies have shown that autophagy closely related to the occurrence and develop-ment of CP.However,several autophagy types in the pancreatic microenvironment play different roles in the progression of CP.The autophagy of acinar cells has a"double-edged sword"effect.PSC autophagy is positively correlated with its activation,while the role of autophagy of inflammatory cells is still unclear.This study focused on some key cells in the CP microenvironment and explored the role and mechanism of autophagy in the progression of CP.
