Research progress of ferroptosis pathway in rheumatoid arthritis
10.3969/j.issn.1000-484X.2024.10.031
- VernacularTitle:铁死亡通路在类风湿关节炎中的研究进展
- Author:
Lili CHENG
1
;
Shuangshuang SHANG
;
Yang GE
;
Zhongfu TANG
;
Changping XU
;
Ming LI
;
Chuanbing HUANG
Author Information
1. 安徽中医药大学第一附属医院,合肥 230031
- Keywords:
Ferroptosis pathway;
Rheumatoid arthritis;
Iron overload;
Inflammation
- From:
Chinese Journal of Immunology
2024;40(10):2202-2206,2213
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a common chronic autoimmune disease with synovitis as its pathological basis and erosive arthritis as its main symptom.Pathogenesis of RA is complex,combination of genetic factors,environmental factors,immune cells,cytokines and autoantibodies causes joint injury,bone destruction and multi-system disease of RA.However,the above mecha-nisms can not fully explain the poor prognosis,high disability rate and poor clinical treatment effect of RA.Therefore,exploring new pathogenesis and therapeutic targets of RA is the focus of RA research.In recent years,with the deepening of RA research,it has been found that there is a new form of cell death in pathological process of RA,namely ferroptosis.Ferroptosis is a type of cell death caused by inhibition of glutathione peroxidase activity and accumulation of lipid reactive oxygen species.Previous studies have con-firmed the close correlation between RA and ferroptosis,this paper mainly explores ferroptosis-related signal pathways that affect the change and development of RA disease from the perspective of regulating the main signal pathways of ferroptosis,so as to find new therapeutic targets for RA and new therapeutic ideas for research.
