Research progress on commonly used expression systems and applications of virus-like particles
10.3969/j.issn.1000-484X.2024.10.030
- VernacularTitle:病毒样颗粒常用表达系统及应用研究进展
- Author:
Xingfu SHU
1
,
2
;
Yao CHEN
;
Jinxian SU
;
Xiaomei MA
;
Jialin BAI
;
Zhongren MA
;
Haixia ZHANG
Author Information
1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030
2. 西北民族大学生命科学与工程学院,兰州 730030
- Keywords:
Virus-like particles;
Expression system;
Vaccine;
Drug delivery
- From:
Chinese Journal of Immunology
2024;40(10):2194-2201
- CountryChina
- Language:Chinese
-
Abstract:
Virus-like particles(VLPs)are nanoparticles that are self-assembled from one or more structural proteins,which can be arranged in several layers or contain a lipid outer membrane.Due to the lack of genetic material,VLPs cannot infect host cells,but are highly immunogenic and can induce immune responses different from conventional inactivated vaccines.VLPs can be produced using a variety of systems including bacterial,yeast,plant,insect and mammalian cells.Compared with traditional vaccines,VLPs have incomparable advantages,so they are becoming more and more popular in the biomedical field.To date,a series of vaccine candi-dates based on VLPs have been developed for immunization and prevention of various infectious diseases.At the same time,the recent successful application of VLPs in targeted drug delivery and gene therapy has attracted attention.This paper mainly reviews the com-monly used expression systems of VLPs and the research progress of their applications.
