Progress of urine biomarkers in lupus nephritis
10.3969/j.issn.1000-484X.2024.10.029
- VernacularTitle:狼疮性肾炎中相关尿液生物标志物的研究进展
- Author:
Jiali WANG
1
;
Anfeng CUI
;
Weixia HAN
;
Guoye QI
;
Chen WANG
Author Information
1. 山西医科大学第二医院病理科,太原 030001
- Keywords:
Biomarkers;
Lupus nephritis;
Renal biopsy;
Kidney damage;
Disease activity;
Histological type
- From:
Chinese Journal of Immunology
2024;40(10):2189-2193
- CountryChina
- Language:Chinese
-
Abstract:
Lupus nephritis(LN)is an immune-complex nephritis caused by renal involvement in systemic lupus erythemato-sus(SLE).It is one of the main causes of death in SLE and the end-stage renal disease(ESKD).Early diagnosis,effective treatment and reduction of recurrence are important means to delay LN entering ESKD.Renal biopsy is the"gold standard"for diagnosis and determination of LN typing and activity,but it is invasive and not easy to repeat.Therefore,there are still some clinical indicators that can accurately monitor the degree of kidney damage at an early stage,effectively reflect the histological type,disease activity,and judge the curative effect and prognosis.This article reviews the studies on urine biomarkers related to LN,in order to provide ideas for basic research and clinical treatment of LN.
