Research progress of endoplasmic reticulum stress in immune cells

VernacularTitle:内质网应激在免疫细胞中的作用研究进展
Author: Tao LU ¹ ; Yin ZHANG ; Chuan LI ; Shide LIN
Author Information

1. 遵义医科大学附属医院感染科,遵义 563000
Keywords: Endoplasmic reticulum stress; Immune cells; Immune disorders; New therapies
From: Chinese Journal of Immunology 2024;40(9):2011-2016,后插1-后插2
CountryChina
Language:Chinese
Abstract: Immune response occurs in a variety of cellular stresses that severely disrupt function of endoplasmic reticulum(ER),leading to accumulation of misfolded or unfolded protein in ER lumen,resulting in endoplasmic reticulum stress(ERS).ERS triggers unfolded protein response to restore ER homeostasis,but its duration is too long and can lead to cell apoptosis.Although sus-tained ERS can lead to an increase in pro-inflammatory cytokines that induce inflammatory responses and activate immune responses,causal relationship between ERS and immune responses has not been established.This review summarizes role of ERS in inducing im-mune cell differentiation,cytokine expression and immune function,and further illustrates regulatory role of ERS in pathogenesis of immune disorders,which is helpful to explore new therapies for ERS-related diseases.