Research progress of semaphorins in rheumatoid arthritis
10.3969/j.issn.1000-484X.2024.09.034
- VernacularTitle:信号素在类风湿关节炎发病机制中的作用研究进展
- Author:
Dan OUYANG
1
;
Yuanzhi MA
;
Xin LI
;
Jianzhong CAO
Author Information
1. 湖南中医药大学中医诊断学湖南省重点实验室,长沙 410208
- Keywords:
Rheumatoid arthritis;
Semaphorins;
Synovial inflammation;
Angiogenesis;
Bone destruction;
Therapeutic target
- From:
Chinese Journal of Immunology
2024;40(9):2001-2005
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a common systemic autoimmune disease.Chronic synovial inflammation,angiogene-sis,pannus formation,joint destruction of cartilage and bone are important pathological characteristics in RA.Semaphorins(Sema)is a kind of secreted and membrane-bound glycoprotein with nerve guiding effect.Recent studies have shown that Sema family members play an important role in the various pathological stages of RA.Therefore,this paper reviews and discusses the latest research progress on the involvement of Sema family members in different pathological links of RA,which can help to find new feasible targets for RA and provide new research ideas for the pathogenesis of RA.
