Research progress of mTOR regulating T cell proliferation and function
10.3969/j.issn.1000-484X.2024.09.033
- VernacularTitle:mTOR调控T细胞增殖与功能的研究进展
- Author:
Han WU
1
;
Hong HUANG
;
Ouyang YI
;
Mingyue HU
;
Liang LIU
;
Xiong CAI
Author Information
1. 湖南中医药大学科技创新中心,长沙 410208
- Keywords:
mTOR;
T lymphocytes;
Carbohydrate metabolism;
Lipid metabolism;
Natural compounds
- From:
Chinese Journal of Immunology
2024;40(9):1992-2000
- CountryChina
- Language:Chinese
-
Abstract:
The mechanistic target of rapamycin(mTOR)plays a pivotal role in various cellular processes,including growth,proliferation and differentiation.As an essential component of the human immune system,T lymphocytes are regulated by mTOR through metabolic pathways such as carbohydrate metabolism and lipid metabolism.This article summarizes the critical role of mTOR in T cell differentiation and reviews recent advances in natural compounds that modulate T cells via mTOR.These findings contribute to the development of mTOR-targeted therapies for diseases.
