Advances of CD133 in immune escape and diagnosis of tumor

VernacularTitle:CD133在肿瘤免疫逃逸及诊断的研究进展
Author: Duoduo CHEN ¹ ; Di HU ; Bingqing LIU ; Qi LI ; Hongrui WANG ; Ming YANG
Author Information

1. 北华大学,吉林 132000
Keywords: CD133; Immune escape; Tumor stem cells; Marker
From: Chinese Journal of Immunology 2024;40(9):1986-1991
CountryChina
Language:Chinese
Abstract: Cancer stem cells(CSCs)are a small group of cells found in tumors that have same self-renewing properties as nor-mal stem cells.In recent years,with continuous development of science and technology in various aspects,people's research on tumor diseases has been deepened.CSCs has been defined as a key factor in promoting tumor development,especially participating in pro-moting tumor recurrence,metastasis,chemotherapy resistance,etc.Currently,CD133 has become one of popular CSCs markers,and can be highly expressed in a variety of CSCs.CD133 is closely related to diagnosis of cancer diseases,and plays an important role in dignosis and drug targeting for gastric cancer,lung cancer,brain tumor,liver cancer,ovarian cancer and colorectal cancer.This article reviews structure,function,immune mechanism escape of CD133,signal pathway of CD133 in tumorigenesis,and correlation of CD133 with various tumors as well.