Advances in studies of Th17/Treg cells in prostatic disease

VernacularTitle:Th17/Treg细胞在前列腺疾病中的作用研究进展
Author: Jiawei LI ¹ ; Jialin MENG ; Chaozhao LIANG
Author Information

1. 安徽医科大学第一附属医院泌尿外科,合肥 230022
Keywords: Th17 cell; Treg cell; Prostatitis; Prostate cancer
From: Chinese Journal of Immunology 2024;40(9):1981-1985
CountryChina
Language:Chinese
Abstract: N?ive CD4+T cells play a key role in the initiation and maintenance of immune response.In the effect of cytokines and costimulatory molecules,they differentiate into Th1,Th2,Treg and Th17.Increasing evidences indicated that Th17 and Treg cells produce a significant effect on immune stability,autoimmune disease and cancer.Chronic prostatitis/chronic pelvic pain syndrome(CP/CPPS)is the most common type of prostatitis,accounting for 90%～95%,which is closely correlated with the progression of be-nign prostatic hyperplasia and prostate cancer.Benign and malignant diseases of the prostate share much similarity in immune microen-vironment.Thus,this review summarizs the latest research progress on the mechanism of Th17/Treg cells in prostatic disease.