Gut-joint axis:Relationship between intestinal mucosal immunity and rheumatoid arthritis

VernacularTitle:肠-关节轴:肠黏膜免疫与类风湿关节炎的关系探讨
Author: Peng JI ¹ ; Zhou SHA ; Wei ZHANG ; Liyun SHI
Author Information

1. 南京中医药大学医学院·整合医学学院,南京 210023
Keywords: Intestinal mucosal immunity; Rheumatoid arthritis; Immune cells; Gut microbiota
From: Chinese Journal of Immunology 2024;40(9):1969-1974
CountryChina
Language:Chinese
Abstract: Rheumatoid arthritis(RA)is a type of chronic autoimmune disease with unknown etiology and inflammatory syno-vitis.The occurrence and development of RA are closely related to intestinal mucosal immunity.Imbalance of intestinal flora,impaired intestinal barrier integrity,production of local autoantibodies and changes of immune cells in the lamina propria are all potential risks of RA.We explored the relationship between intestinal mucosal immunity and RA(gut-joint axis)in detail,with respect to provide novel thought and theoretical basis for the treatment of RA.