Research progress of PD-1/PD-L1 signaling pathway in immune regulation of different organs in sepsis

VernacularTitle:PD-1/PD-L1信号通路在脓毒症不同器官免疫调控中的研究进展
Author: Dengrong ZHANG ¹ ; Chunyao LIU ; Tingting BU ; Zhenxie LUO ; Xianping LONG ; Song WANG
Author Information

1. 遵义医科大学附属医院急诊科,遵义 563000
Keywords: Sepsis; PD-1/PD-L1; Immunoregulation
From: Chinese Journal of Immunology 2024;40(8):1789-1792,封3
CountryChina
Language:Chinese
Abstract: Sepsis is a life-threatening organ dysfunction caused by the imbalance of host immune response to infection,which immune regulation mechanism is complex and has not been clarified.Programmed death receptor-1(PD-1)/programmed death recep-tor ligand-1(PD-L1)is a negative co-inhibitory molecule that has attracted much attention in recent years.Studies have shown that PD-1/PD-L1 signaling pathway plays an important immunosuppressive role in sepsis.There are differences in immune regulation mecha-nisms in heart,liver,spleen,lung and kidney,which has not been clarified.Immune regulation of PD-1/PD-L1 in different organs of sepsis is reviewied in this article,which could to provide a new direction for the study of sepsis.