Advances in aspect of GABA metabolism and its regulatory mechanism on T cells
10.3969/j.issn.1000-484X.2024.08.034
- VernacularTitle:GABA代谢及其调控T细胞的作用机制研究进展
- Author:
Haowen JIANG
1
;
Wenmei FAN
Author Information
1. 河北北方学院基础医学院,张家口 075000
- Keywords:
GABA;
GABA-A receptor;
Negative regulation;
Immunity;
Activation;
T cells
- From:
Chinese Journal of Immunology
2024;40(8):1785-1788
- CountryChina
- Language:Chinese
-
Abstract:
Gamma-aminobutyric acid(GABA)is a widely distributed non-protein amino acid.As an inhibitory neurotransmit-ter,GABA plays an important role in negative regulatory process of vertebrate nervous system,which is essential for maintaining the balance of neuronal stimulation and inhibition.With continued exploration,it was found that GABA in immune system and immune cell development can not be ignored.T cells are important components of lymphocytes and the immune system,and participate in the body's cellular immune response to prevent infection and tumor formation.Evidence in recent years showed that GABA can inhibit T cell activation and proliferation,involve in the development of tumor,diabetes and autoimmune diseases.The development of drugs targeting specific diseases is still far away due to structural heterogeneity of GABA-A receptors.In this review,we will review advances in GABA metabolism,mechanism of action for T cells and its relevance with human diseases.
