Advances of studies on minimal persistent inflammation of allergic rhinitis

VernacularTitle:变应性鼻炎最轻持续性炎症的研究进展
Author: Xiangjing CHEN ¹ ; Lifeng ZHANG ; Wei MENG ; Renzhong WANG
Author Information

1. 山东中医药大学附属医院耳鼻喉科,济南 250014
Keywords: Allergic rhinitis; Minimal persistent inflammation; Immune mechanism; Treatment; Review
From: Chinese Journal of Immunology 2024;40(8):1773-1778
CountryChina
Language:Chinese
Abstract: The minimal persistent inflammation(MPI)of allergic rhinitis(AR)is asymptomatic inflammation that occurs locally in the nasal mucosa after exposure to low doses of allergens.With the study of MPI,researchers have realized that this local sub-clinical inflammation in patients with AR not only causes chronic damage to the nasal mucosa,but also increases the hypersensitivity and hyperresponsiveness of allergic airway disease.The concept of MPI has changed our strategy for the treatment of AR,which re-quires that we should not only intervene in the symptomatic exacerbation period,but also intervene in the asymptomatic MPI period.This article systematically reviews the immunological mechanism,adverse effects,and treatment strategies of the MPI,to provide bet-ter treatment for the MPI of AR and reduce the recurrence of AR.