Effects of transdermal meridian-targeted drug delivery of Pelvic Inflammation No.1 formula on IL-10,IL-6,MMP-9 and immune function in patients with chronic pelvic inflammatory disease
10.3969/j.issn.1000-484X.2024.08.025
- VernacularTitle:盆炎1号方经皮经穴靶向透药对慢性盆腔炎患者IL-10、IL-6、MMP-9及免疫功能的影响
- Author:
Qiang FENG
1
;
Hongmei CHEN
;
Ruilian TANG
;
Yuqing WU
;
Yongyan YU
;
Jiping YE
Author Information
1. 海南省儋州市中医医院妇产科,儋州 571700
- Keywords:
Pelvic Inflammation No.1 formula;
Percutaneous meridian-targeted drug penetration therapy;
Chronic pelvic inflammatory disease;
Inflammatory factors;
Immune function;
Symptom score;
Quality of life;
Fibrosis
- From:
Chinese Journal of Immunology
2024;40(8):1735-1739
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the application value of Pelvic Inflammation No.1 formula of transdermal meridian point-targeted drug delivery therapy in the treatment of patients with chronic pelvic inflammatory disease(damp-heat stasis type).Methods:All patients with chronic pelvic inflammatory disease(damp-heat stasis type)visited Danzhou Hospital of Traditional Chinese Medi-cine from August 2017 to March 2021 and were randomly grouped,57 patients in the control group were treated with simple Western medicine,and 57 patients in the observation group were combined with Pelvic Inflammation No.1 formula transdermal meridian target-ed transdermal medication,and the therapeutic efficacies were compared after 3 months of treatment.Results:After treatment,serum matrix metalloproteinase-9(MMP-9),D dimer(D-D),IL-6 and other indexes in the observation group were lower than those in the control group,and IL-10 was higher than that in the control group,the difference was statistically significant(P<0.05).After treat-ment,the carbohydrate antigen CA125 in the observation group was lower than that in the control group,and the CD4+/CD8+and CD4+cells in the observation group were higher than those in the control group(P<0.05).After treatment,the score of summary of health status surveys(SF-36)in the observation group was higher than that in the control group,and the total score of TCM symptoms was lower than that in the control group(P<0.05).The total effective rate in the observation group was 96.49%(55/57),which was higher than 82.46%(46/57)in the control group(P<0.05).Conclusion:For patients with chronic pelvic inflammatory disease(damp-heat stagnation type),combined with Pelvic Inflammation No.1 formula transdermal via acupoints targeted drug therapy can help to regu-late inflammatory factors,regulate immune function,and improve clinical efficacy.
