Immune infiltration mechanism of cuproptosis genes in multiple sclerosis and prediction of potential Chinese medicine treatment
10.3969/j.issn.1000-484X.2024.08.023
- VernacularTitle:多发性硬化铜死亡基因的免疫浸润机制及潜在中药治疗预测
- Author:
Yi MENG
1
;
Wenlan TAN
;
Ying JIANG
;
Yuexia WU
;
Youxue FU
;
Kang CAO
;
Qiongxin ZHANG
;
Xiaoli CHEN
Author Information
1. 广西中医药大学附属瑞康医院,南宁 530011
- Keywords:
Cuproptosis;
Multiple sclerosis;
Immune infiltration;
Bioinformatics;
Immune function
- From:
Chinese Journal of Immunology
2024;40(8):1718-1725,中插2
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the correlation between cuproptosis genes and immune infiltration during the occurrence and development of multiple sclerosis(MS),and to predict the traditional Chinese medicine,to provide theoretical basis for the mecha-nism study of cuproptosis in MS immune infiltration and Chinese medicine to intervene in immune regulation.Methods:The gout chip of MS was downloaded from the GEO database and standardized;based on the processed data,immune cells and functions were ex-tracted and quantified,and the correlation and differences of immune cells and functions were analyzed;at the same time,cuproptosis genes related to MS were screened out,a risk model was constructed,and enrichment analysis was carried out;the prediction of cu-proptosis genes and immune-related biological processes were carried out.Results:① Among immune cells,T follicular helper cell and B cell showed the strongest positive correlation;among the immune functions,parainflammation and typeⅠIFN reponse showed the strongest positive correlation;②B cell,T helper cell and human leukocyte antigen were lowly expressed in MS patients,while major histocompatibility complex class Ⅰ,parainflammation and typeⅠIFN response were significantly expressed;③ The cupropto-sis genes associated with MS were SLC31A1,PDHA1,NLRP3,MTF1,GLS and DBT,of which DBT was the most likely risk factor for MS;④The occurrence and development of MS involves biological processes such as IL-4 production,T-helper cell differentiation,and acute inflammatory response,which were related to pathways such as arginine biosynthesis,citrate cycle,and propanoate metabo-lism;⑤Banxia,Danshen,Jianghuang and other traditional Chinese medicines may be used as potential molecular drug sources.Con-clusion:The expression of cuproptosis gene is closely related to MS-related immune cells and functions,which can provide support for the basic research of MS.
