Research progress of cancer vaccines based on virus-like particles

VernacularTitle:基于病毒样颗粒的癌症疫苗研究进展
Author: Xingfu SHU ^{1
,

2} ; Yao CHEN ; Xiaomei MA ; Jinxian SU ; Jialin BAI ; Haixia ZHANG ; Zhongren MA
Author Information

1. 西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,兰州 730030
2. 西北民族大学生命科学与工程学院,兰州 730030
Keywords: Tumor; Vaccines; Virus-like particles
From: Chinese Journal of Immunology 2024;40(8):1590-1594
CountryChina
Language:Chinese
Abstract: Active immunotherapy for cancer aims to treat disease by inducing effective cellular immunity and humoral immunity.Research on virus-like particles(VLPs)vaccines has made tremendous progress in recent years,dramatically reducing morbidity and mortality from some infectious diseases.VLPs are nanoparticles self-assembled from one or more structural proteins,with highly ordered repeat sequences and good immunogenicity,which can induce strong cellular immune and humoral immune responses.VLPs can overcome immunosuppressive state of tumor microenvironment,break self-tolerance,and trigger strong cytotoxic T lymphocyte activity,which is critical for both viral clearance and destruction of cancer cells.This article mainly reviews current research progress of VLPs-based cancer vaccines and potential defects of VLPs as vaccine carriers in development of cancer vaccines.