Regulatory molecules related with microglia-neuron two-way interaction
10.3969/j.issn.1000-484X.2024.07.033
- VernacularTitle:小胶质细胞-神经元双向作用相关调节分子
- Author:
Juan GAO
1
;
Gang SU
;
Zhenchang ZHANG
;
Qionghui WU
;
Wei CHEN
;
Manxia WANG
Author Information
1. 兰州大学第二医院神经内科,兰州 730030
- Keywords:
Microglia;
Neurons;
Two-way interaction;
Regulatory molecules
- From:
Chinese Journal of Immunology
2024;40(7):1542-1547
- CountryChina
- Language:Chinese
-
Abstract:
As resident immune cells of central nervous system(CNS),microglia play a key role in immune surveillance and tissue repair.They can be activated by various types of pathological factors to form M1 or M2 phenotype,which mediates neuroinflam-mation or neuroprotective effects.At the same time,when the homeostasis of the microenvironment in which the neuron is located is broken,"signal"molecules are also released to induce microglial activation through ligand-receptor binding.Therefore,the regulation of microglia-neuron connection is of great significance for treatment of nervous system diseases.This article reviews the signaling mole-cules involved in the two-way interaction between microglial cells and neurons,and elucidates the immune mechanisms of microglia-neuron,thus providing a basis for targeted treatment of CNS diseases related to microglia activation.
