Research progress of ubiquitination involved in autophagy in regulating innate immune response
10.3969/j.issn.1000-484X.2024.07.031
- VernacularTitle:泛素化参与自噬调节固有免疫应答的研究进展
- Author:
Yiting CAI
1
;
Wei CHEN
Author Information
1. 浙江大学医学院免疫学研究所,杭州 310058
- Keywords:
Ubiquitination;
Autophagy;
Innate immunity;
Type Ⅰ interferon
- From:
Chinese Journal of Immunology
2024;40(7):1525-1535
- CountryChina
- Language:Chinese
-
Abstract:
Innate immune response is the first line of immune defense in our body against invaded pathogens.After receive pathogen stimulation,immune cells synthesize abundant type Ⅰ interferons(IFNs)through activating three different signaling path-ways to establish strong antiviral immune response.Mounting evidences have revealed that selective autophagy participates in the regu-lation of innate type Ⅰ IFN response and prevents the excessive activation of immune responses.E3 ubiquitin ligases transfer different type of polyubiquitin chains to some key signaling proteins,and trigger the selective degradation of these proteins through autophago-some-lysosome pathway.Therefore,autophagy and E3 ubiquitin ligases integrate the spatiotemporal regulation of innate type Ⅰ IFN response.In this review,we summarized current data elucidating the critical role of autophagy and E3 ubiquitin ligases in the regula-tion of innate immune response.
