Triggering receptor expressed on myeloid cells 2——a new target for treatment of ischemic stroke
10.3969/j.issn.1000-484X.2024.07.028
- VernacularTitle:髓样细胞触发受体2——缺血性脑卒中治疗的新靶点
- Author:
Zhuyue MIAO
1
;
Ruheng WEI
;
Kexin LIU
;
Guangyuan HAN
;
Lijuan SONG
;
Cungen MA
Author Information
1. 山西中医药大学神经生物学研究中心/国家中医药管理局多发性硬化益气活血重点研究室,晋中 030619
- Keywords:
TREM2;
Microglia;
Ischemic stroke
- From:
Chinese Journal of Immunology
2024;40(7):1510-1514
- CountryChina
- Language:Chinese
-
Abstract:
Ischemic stroke,with a high disability and mortality rate,seriously endangers human health.Pathological process of ischemic stoke involves participations of various cells such as microglia and astrocytes.Among them,microglia,as innate immune cells in central nervous system(CNS),play an important role whether in physiological or pathological states.Triggering receptor expressed on myeloid cells 2(TREM2)is an immunoglobulin like receptor mainly existing on microglia in CNS,and can bind to a variety of ligands,which can negatively regulate autoimmunity and inflammation.In addition,TREM2 can mainly play an important role in process of proliferation,phagocytosis,survival and expressions of inflammatory factors.This article focused on biological characteristics of TREM2 on microglia,corresponding ligands and its signaling pathways,discussing regulation of TREM2 in ischemic stroke and its potential therapeutic effects,in order to provide an new target for prevention and treatment of ischemic stroke.
