Role of extracellular vesicles in treatment of systemic lupus erythematosus
10.3969/j.issn.1000-484X.2024.06.032
- VernacularTitle:细胞外囊泡在系统性红斑狼疮中的研究新进展
- Author:
Ying ZHAO
1
,
2
;
Bo DIAO
;
Yingying YANG
;
Yaxuan LIU
Author Information
1. 中部战区总医院呼吸与危重症医学科,武汉 430070
2. 武汉科技大学医学院,武汉 430065
- Keywords:
Systemic lupus erythematosus;
Extracellular vesicles;
Exosomes;
Microparticles;
Apoptotic bodies
- From:
Chinese Journal of Immunology
2024;40(6):1307-1314
- CountryChina
- Language:Chinese
-
Abstract:
Systemic lupus erythematosus(SLE)is a heterogeneous autoimmune disease that affects multiple organs.Extracel-lular vesicles(EVs),including exosomes,microparticles and apoptotic bodies,are released by most types of cells and carry nucleic acids,proteins and lipids,which play a crucial role in communication among cells.In SLE,extracellular vesicles can act as autoadju-vants to enhance the formation of immune complexes and maintain inflammatory states.In this review,the biological origin and mes-senger role of EVs in cell communication are reviewed,and the research progress of EVs in immune regulation and pathogenesis in SLE is highlighted.
