Research progress of ULK1 in inflammatory diseases
10.3969/j.issn.1000-484X.2024.06.031
- VernacularTitle:ULK1在炎症性疾病中的研究进展
- Author:
Wanting LIU
1
;
Chang XU
;
Chongyang WANG
;
Yilan SONG
;
Li LI
;
Guanghai YAN
Author Information
1. 吉林省过敏性常见疾病免疫与靶向研究重点实验室,延边大学医学院,延吉 133002
- Keywords:
ULK1;
Complex;
Autophagy;
Mitochondrial oxidative stress;
Inflammation
- From:
Chinese Journal of Immunology
2024;40(6):1302-1306,1314
- CountryChina
- Language:Chinese
-
Abstract:
UNC-51-like kinase 1(ULK1)is an important factor involved in regulating the initiation of autophagy.ULK1 regu-lates inflammatory cytokines through autophagy and mitochondrial oxidative stress,and is involved in the pathological processes of var-ious diseases.ULK1 and its complexes are regulated by rapamycin(mTOR)and AMP-activated protein kinase(AMPK)to initiate au-tophagy,thereby exerting differential effects on a variety of inflammatory diseases.In inflammatory diseases,mitochondrial oxidative stress can induce ULK1 into the nucleus to accelerate apoptosis.Therefore,ULK1 plays different important roles in inflammatory dis-eases.For example,ULK1 initiates airway epithelial mitochondrial autophagy in asthma,participates in mitochondrial oxidative stress in acute liver failure,affects related inflammatory factors in atherosclerosis,and modulates beneficial effects of autophagy in diabetes.This article reviews the biological function of ULK1,its impact on inflammatory diseases and the research progress of targeted drugs.
