Research status of CXCL12/CXCR4 axis in HIV infection and TCM syndromes of AIDS
10.3969/j.issn.1000-484X.2024.06.030
- VernacularTitle:CXCL12/CXCR4轴在HIV感染及艾滋病中医证候中的研究现状
- Author:
Xiaoyu CHEN
1
;
Shiping XIE
;
Miao ZHANG
;
Sa LIU
;
Suna MA
;
Juan WANG
Author Information
1. 河南中医药大学,郑州 450046
- Keywords:
CXCL12/CXCR4;
HIV infection;
AIDS;
TCM syndrome;
Research status
- From:
Chinese Journal of Immunology
2024;40(6):1297-1301
- CountryChina
- Language:Chinese
-
Abstract:
The structure and biological function of CXCL12/CXCR4 are the basis of physiological and pathological function.Combination of HIV-1 envelope protein and CXCR4 will promote the entry of virus into host cells.CXCL12 can reduce the number of CXCR4 through rapid endocytosis and inhibit the replication and transmission of HIV.The interaction of CXCL12/CXCR4 axis with in-flammation and autophagy plays an important role in HIV infection.Previous research has found that gene expression profiles of differ-ent TCM syndromes of acquired immunedeficiency syndrome(AIDS)are different.CXCR4 has different expression in AIDS,lung and spleen qi deficiency syndrome,Qi Yin deficiency syndrome and dampness heat syndrome,which is related to chemokine signaling pathway;the differential gene CXCR4 in peripheral blood of AIDS patients with lung and spleen qi deficiency syndrome is related to au-tophagy process.According to the intervention of Yiaikang Capsule,CXCR4 expression is increased,indicating that Yiaikang Capsule can regulate the expression of autophagy related genes.Research on the role of CXCL12/CXCR4 in TCM syndromes of AIDS is condu-cive to better play the therapeutic advantages of TCM and provide a new direction for gene targeted therapy.
