Research progress of osteoporosis based on Th17/Treg balance
10.3969/j.issn.1000-484X.2024.06.028
- VernacularTitle:基于Th17/Treg平衡探讨骨质疏松症研究进展
- Author:
Jiayu WANG
1
;
Chunlu YAN
;
Fangyu AN
;
Lingqing YUAN
;
Xiaxia WANG
Author Information
1. 甘肃中医药大学,兰州 730000
- Keywords:
Osteoporosis;
Bone immunology;
Th17 cells;
Treg
- From:
Chinese Journal of Immunology
2024;40(6):1283-1291
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis(OP)is a chronic systemic metabolic bone disease.In recent years,with development of population aging,incidence of OP is also increasing,bringing huge economic burden to family and society.There are many causes of OP,such as aging,oxidative stress,epigenetic and many other aspects,and with further development of research,inflammatory factors and other bone immunology into people's vision.Th17 cells are effector T cell subpopulation that induce development of inflammation and promote bone loss.On the contrary,Treg can maintain their own tolerance and further suppress their own immunity,thus playing a bone protective role.Under physiological conditions,Th17/Treg balance can maintain bone homeostasis,while under pathological condi-tions,disruption of Th17/Treg balance can lead to bone loss.Based on this,this paper will review pathways and cytokines mediating Th17/Treg balance in OP,in order to provide new ideas and methods for treatment of OP.
