LUNX gene serve as a prognostic biomarker for non-small cell lung cancer associated with immune cell infiltration
10.3969/j.issn.1000-484X.2024.06.014
- VernacularTitle:LUNX基因作为与免疫细胞浸润相关的非小细胞肺癌预后生物标志物
- Author:
Xinran LU
1
;
Ning WANG
;
Zhiqiang LIU
;
Yuexia ZHAO
;
Xinqiao CAO
;
Xiaojia LIU
Author Information
1. 衡水市人民医院,衡水 053000
- Keywords:
Non-small cell lung cancer;
Lung specific X protein;
Immune cell infiltration;
Biomarkers
- From:
Chinese Journal of Immunology
2024;40(6):1197-1202
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate whether the lung specific X protein(LUNX)gene can serve as a prognostic biomarker for non-small cell lung cancer related to immune cell infiltration.Methods:A total of 280 non-small cell lung cancer patients admitted to Hengshui People's Hospital from January 2020 to January 2023 were selected to detect the expression of LUNX gene in cancer tissue and adjacent tissues,and to analyze the relationship between LUNX gene and immune cell infiltration and prognosis survival status in the tumor microenvironment.Results:Compared with adjacent tissues,the expression level and positive rate of LUNX gene in non-small cell lung cancer tissue were increased,which were related to differentiation degree,lymph node metastasis and tumor staging(P<0.05).GEPIA database analysis showed that the LUNX gene was only slightly expressed or not expressed in other tissues,while its expression was elevated in LUAD and LUSC(P<0.05).The copy number of LUNX gene and LUNX gene were related to the level of immune cell infiltration(P<0.05).Survival analysis showed that high expression of the LUNX gene was associated with patient survival prognosis(P<0.05).Conclusion:The LUNX gene is specifically expressed in non-small cell lung cancer tissue,affecting the level of immune cell infiltration in non-small cell lung cancer,leading to an imbalance in the immune microenvironment,and is an important mechanism for causing patients prognostic death,which can be used as a prognostic biomarker for evaluating immune cell infiltration.
