Microenvironmental alterations and therapeutic advances in multiple myeloma bone disease
10.3969/j.issn.1000-484X.2024.05.016
- VernacularTitle:多发性骨髓瘤骨病微环境改变与治疗进展
- Author:
Yixin WEI
1
;
Liansheng ZHANG
;
Lijuan LI
;
Xiaosha LI
Author Information
1. 兰州大学第二医院,兰州 730030
- Keywords:
Multiple myeloma;
Bone disease;
Bone marrow microenvironment;
Therapy
- From:
Chinese Journal of Immunology
2024;40(5):1010-1015
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma bone disease(MBD)is a common clinical complication in patients with multiple myeloma(MM),and the occurrence of bone-related events seriously affects the quality of survival and prognosis of patients.The pathogenesis of MBD involves an imbalance in physiologic bone remodeling:overactivation of osteoclasts,suppression of osteoblasts,and multiple cell-cytokine interactions in the microenvironment,including osteoblasts,bone marrow stromal cells,and immune cells.The current treatment of MBD is based on standard antimyeloma therapy to control tumor progression,along with the use of bone-related drugs act-ing on bone remodeling within the indications.To prevent bone destruction.In order to prevent bone destruction,it is essential to in-duce new bone formation to repair the existing lesions while resisting bone resorption,and a variety of novel bone-targeting drugs are currently demonstrating anti-osteopathic effects in preclinical and clinical trials.This article summarizes new advances in the mecha-nisms of bone remodeling and treatment of MBD.
