Effect of arginine metabolism on tumor growth and tumor immunity
10.3969/j.issn.1000-484X.2024.05.015
- VernacularTitle:精氨酸代谢对肿瘤生长及肿瘤免疫的影响
- Author:
Jiuyan LI
1
;
Liancheng LEI
;
Jing HUANG
Author Information
1. 吉林大学第一医院检验科,长春 130021
- Keywords:
Arginine metabolism;
Tumor;
Tumor immunity
- From:
Chinese Journal of Immunology
2024;40(5):999-1009
- CountryChina
- Language:Chinese
-
Abstract:
The importance of amino acid metabolism has been gradually recognized,and the relationship between arginine me-tabolism and tumors has become a hot topic.Arginine is a conditionally essential amino acid,which is closely related to the occur-rence,growth and metastasis of tumors.The formation of an immunosuppressive microenvironment,and the phenotypic changes,mat-uration and functional status of myeloid immune cells are also inseparable from arginine metabolism.This article mainly elucidates how arginine metabolism affects tumors and the role of arginine in anti-tumor immunity,summarizes the main myeloid immune cells in the tumor microenvironment,and briefly summarizes the tumor treatment strategies that target the arginine metabolism pathway.
