Regulation and its mechanisms of BMI1 molecule on self-renewal and tumor immune evasion of cancer stem cells
10.3969/j.issn.1000-484X.2024.05.014
- VernacularTitle:BMI1分子调控肿瘤干细胞自我更新及免疫逃逸的作用机制
- Author:
Hua YU
1
;
Guiqing DING
;
Xiaodong CHENG
Author Information
1. 上海中医药大学附属岳阳中西医结合医院临床免疫研究所,上海 200437
- Keywords:
BMI1;
Cancer stem cells;
Self-renewal;
Migration and invasion;
Drug-resistance;
Immune evasion
- From:
Chinese Journal of Immunology
2024;40(5):992-998
- CountryChina
- Language:Chinese
-
Abstract:
B-cell-specific moloney murine leukemia virus integration site 1(BMI1)molecule is one of the members of the family of the Polycomb group(PcG)protein.As a crucial marker of stem cells,it maintains the normal physiological functions of the or-ganisms through regulating expression of the related genes transcriptionally.It was reported that BMI1 is also a crucial molecule which affects pathogenesis and progression of malignant tumors.Therefore,it plays an important role in regulating self-renewal,migration,invasion,drug-resistance,and as well as immune evasion of cancer stem cells(CSCs),which is associated with recurrence and metas-tasis of cancer.In this review,based on the research progresses during recent years,molecular structure and biological function of BMI1 were illustrated.Furthermore,regulation and its mechanisms of BMI1 molecule on the self-renewal,migration and invasion,drug-resistance and immune evasion of CSCs were also elaborated.It indicated that investigation of BMI1 molecule as a novel potential target in cancer immunotherapy would be much valuable and significant.
