Prognostic significance and immune correlation analysis of SQLE in pan-cancer
10.3969/j.issn.1000-484X.2024.05.009
- VernacularTitle:SQLE在泛癌中的预后意义及免疫相关分析
- Author:
Lixiu ZHU
1
;
Wei XIONG
;
Guoqiang XU
;
Ruixue CAO
;
Tianrui XU
Author Information
1. 昆明医科大学第三附属医院,昆明 650118
- Keywords:
SQLE;
Bioinformatics analysis;
Pan-cancer;
Prognostic biomarker;
Immunity
- From:
Chinese Journal of Immunology
2024;40(5):952-960
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of SQLE on the biological characteristics of pan-cancer,using bioinformatics methods to predict and analyze the correlation between SQLE and the clinical prognosis and immunity of pan-cancer.Methods:The ex-pression level of SQLE in tumor and normal tissues and its correlation with different clinical stages of pan-cancer were analyzed,and the relationship between SQLE expression and overall survival and tumor microenvironment were evaluated.Gene enrichment analysis was conducted to study the biological functions and signaling pathways related to SQLE gene,then,calculate the correlation between SQLE gene and tumor mutation load and microsatellite instability,and analyze the correlation between SQLE gene and immunomodula-tory genes.Results:SQLE gene was highly expressed in variety of tumors,and differentially expressed in different tumor stages.High expression of SQLE was a risk factor in variety of tumors.Patients with high expression of SQLE hade a worse prognosis.SQLE was cor-related with TMB and MSI,and involved in tumor development through different pathways.Conclusion:SQLE,as a valuable prognos-tic biomarker and new therapeutic target for variety of cancers,has certain application value in basic research and clinical treatment of various cancers.
