Regulation of Notch signaling pathway in immune responses during infection
10.3969/j.issn.1000-484X.2024.04.034
- VernacularTitle:Notch信号通路在感染过程中对免疫应答的调控作用
- Author:
Wenhao MAI
1
;
Chuxi CHEN
;
Qiaoyuan LIU
;
Yunshan NING
;
Yan LI
Author Information
1. 南方医科大学检验与生物技术学院,广州 510515
- Keywords:
Notch signaling pathway;
Infection;
Immune response;
Macrophages;
Dendritic cells;
T cells
- From:
Chinese Journal of Immunology
2024;40(4):872-879
- CountryChina
- Language:Chinese
-
Abstract:
Innate and adaptive immune responses initiated by infection depend on recognition and control of pathogens by macrophages,dendritic cells,T cells and so on.Notch signaling pathway is a highly conserved pathway,which is activated by interac-tion of receptors and ligands,thus coordinating important life processes of cells.At present,it has been confirmed that Notch signaling pathway is involved in development,differentiation,maturation and activation of many kinds of immune cells,and plays an important role in infectious diseases.In this review,we mainly focus on the role of Notch signaling pathway in immune regulation during different pathogens infection and its interaction with other signaling pathways.Additionally,therapeutic methods and challenges of developing Notch signaling as a target in infectious diseases are also discussed.
