Effects of mycotoxins on immune response of dendritic cells
10.3969/j.issn.1000-484X.2024.04.032
- VernacularTitle:真菌毒素对树突状细胞免疫应答的影响
- Author:
Huan YU
1
;
Guofu SHANG
;
Sha OU
;
Liang HONG
;
Zhu ZENG
;
Zuquan HU
Author Information
1. 贵州医科大学生物与工程学院,贵州省感染免疫与抗体工程特色重点实验室,省部共建药用植物功效与利用国家重点实验室,贵阳 550025
- Keywords:
Mycotoxins;
Immunotoxicity;
Dendritic cells;
Antigen-presenting cells
- From:
Chinese Journal of Immunology
2024;40(4):862-865,871
- CountryChina
- Language:Chinese
-
Abstract:
Mycotoxins are secondary metabolites produced by pathogenic fungi.They often contaminate various crops,and are detrimental to human and animal health.Mycotoxins have a variety of toxic effects,such as neurotoxicity,hepatotoxicity,immunotox-icity,teratogenicity,and carcinogenicity.However,the mechanism of immunotoxicity is still unclear.Dendritic cells(DCs),as the most potent antigen presenting cells,play a vital role in initiating innate and adaptive immune responses.Previous studies have found that mycotoxins can affect the endocytosis of DCs,the ability to stimulate T cell activation,the secretion of cytokines and chemokines.Thus,this review is aim to summarize the effects of mycotoxins on DCs-mediated immune responses,which may provide reference for researches to clarify the immunotoxicity mechanism of mycotoxins.
