Immunosuppressive effect of metabolic"waste"lactic acid in tumor microenvironment
10.3969/j.issn.1000-484X.2024.04.028
- VernacularTitle:代谢"废物"乳酸在肿瘤微环境中的免疫抑制作用
- Author:
Siyu YUAN
1
;
Junjie HOU
;
Pianhong ZHANG
Author Information
1. 浙江大学医学院附属第二医院营养科,杭州 310009
- Keywords:
Lactic acid metabolism;
Immunosuppressive;
Tumor microenvironment
- From:
Chinese Journal of Immunology
2024;40(4):832-839
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,the tumor microenvironment(TME)has garnered significant attention from scientists.It is a com-plex system composed of tumor cells,cancer-associated fibroblasts(CAFs),immune cells,blood vessels,extracellular matrix,sur-rounding supportive tissues and their metabolic environment.Two fundamental characteristics of this system are immune escape and metabolic changes(the shift from aerobic to anaerobic metabolism of glucose,leading to lactate production).Although lactate has tra-ditionally been considered a metabolic"waste"product in the TME,it is now widely recognized that the increase in lactate and the acidification of the tumor microenvironment play key roles in tumor development and progression,including immune escape,tissue in-vasion/tumor metastasis,angiogenesis and tumor drug resistance.Therefore,studying the regulatory mechanisms of lactate metabo-lism,immune suppression,angiogenesis,and tumor drug resistance in the TME can provide a theoretical basis and practical evidence for new therapeutic strategies targeting the TME.
