Relationship of CD4+T lymphocytes and related cytokines with prognosis of patients with chronic heart failure
10.3969/j.issn.1000-484X.2024.04.022
- VernacularTitle:慢性心衰患者CD4+T淋巴细胞亚群及相关细胞因子与预后的关系研究
- Author:
Likun ZHANG
1
;
Jianjiao CUI
;
Yang LIU
Author Information
1. 锦州医科大学附属第三医院医学检验中心,锦州 121000
- Keywords:
Chronic heart failure;
CD4+T lymphocytes;
Cytokines;
Prognosis
- From:
Chinese Journal of Immunology
2024;40(4):802-805
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship of CD4+T lymphocytes and related cytokines with the prognosis of pa-tients with chronic heart failure.Methods:The relevant data of 200 patients with chronic heart failure admitted to the Third Affiliated Hospital of Jinzhou Medical University between January 2018 and November 2020 were retrospectively analyzed.T lymphocytes and re-lated cytokines in all patients were measured.The patients were followed up for 1 year to evaluate the prognosis,and dividied the levels of CD4+T lymphocytes and related cytokines in the good prognosis group and the poor prognosis group were compared.The patients'da-ta were analyzed to screen the prognostic factors.Results:The incidence of poor prognosis was 20.5%.The level of Th1 cells and Th1/Th2 in the poor prognosis group were significantly higher than those in the good prognosis group,and the level of Th2 cells was signifi-cantly lower than that in the good prognosis group(P<0.05).The levels of tumor necrosis factor-α(TNF-α)and interferon-gamma(IFN-γ)in the poor prognosis group were higher than those in the good prognosis group.The levels of IL-4 and IL-6 were lower than those in the good prognosis group(P<0.05).Univariate analysis and multivariate Logistic regression analysis showed that decreased levels of Th2 cells and Hb,increased Th1 cells,BNP and cardiac function were prognostic factors(P<0.05).Conclusion:The levels of CD4+T lymphocytes and related cytokines are abnormal in patients with chronic heart failure,which are closely related to the prognosis.
