Correlation of inflammatory cytokines with different characteristics of major depressive disorder
10.3969/j.issn.1000-484X.2024.04.020
- VernacularTitle:炎症细胞因子与不同特征重性抑郁障碍的相关性
- Author:
Xue MIN
1
;
Yanfang WANG
;
Hong YAO
;
Yunqiao ZHANG
Author Information
1. 山西医科大学基础医学院微生物与免疫学教研室,太原 030000
- Keywords:
Inflammatory cytokines;
Immune;
Major depressive disorder;
Melancholy/underpowered;
Anxiety/somatization
- From:
Chinese Journal of Immunology
2024;40(4):791-795
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the correlation between serum inflammatory cytokines and different characteristics of major depressive disorder.Methods:Serum inflammatory cytokines were detected by ELISA,compared differences of serum inflamma-tory cytokines in melancholy/underpowered depression(MPD)group,anxiety/somatization depression(ASD)group and healthy con-trol(HC)group.Spearman was used to analyze the correlation between inflammatory cytokines and HAMD-17 total score and each fac-tor score,independent risk factors for major depressive disorder with different characteristics were analyzed by binary Logistic regres-sion.Results:Compared with HC group and ASD group,serum IFN-α and IL-6 levels in MPD group were increased(P<0.05);level of serum TNF-α was negatively correlated with the score of cognitive impairment in MPD group(P<0.05),level of serum TNF-α was negatively correlated with the score of cognitive impairment in ASD group(P<0.05),and level of IL-6 was negatively correlated with the score of sleep disorder(P<0.05).Conclusion:Inflammatory cytokines are associated with symptoms of different characteristics of major depressive disorder;IFN-α,TNF-α,IL-6 and IL-10 are independent risk factors for melancholy/underpowered major depres-sive disorder,and IFN-α and IL-6 may serve as objective biomarkers to distinguish melancholy/underpowered from anxiety/somatiza-tion major depressive disorder.
