Expression and clinical significance of FGL2 in GIST
10.3969/j.issn.1000-484X.2024.04.013
- VernacularTitle:FGL2在胃肠间质瘤的表达及临床意义
- Author:
Xianglian ZHANG
1
;
Xingfen WANG
;
Rui LIANG
Author Information
1. 天津医科大学第二医院病理科,天津 300211
- Keywords:
Fibrinogen-like protein 2;
Gastrointestinal stromal tumor;
Tumor infiltration of associated lymphocytes
- From:
Chinese Journal of Immunology
2024;40(4):752-755
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the expression and clinical significance of fibrinogen-like protein 2(FGL2)in gastrointesti-nal stromal tumor(GIST).Methods:Immunohistochemical EnVision two-step method was used to detect expression of FGL2 protein in 158 GIST patients,and correlation between FGL2 protein and clinicopathological parameters was analyzed,and relationship be-tween FGL2 protein and the count of CD3+T,CD8+T,CD20+T and CD68+T of tumor-infiltrating lymphocytes(TILs)in GIST was inves-tigated.Results:Expression of FGL2 protein in GIST was negatively correlated with tumor size,NIH risk grade,necrosis and mitotic image count(P<0.05),there was no significant difference in gender and tumor location(P>0.05).FGL2 expression was associated with low CD3+T cell counts in GIST(P<0.05),while there was no significantly difference with CD8+T,CD20+T and CD68+T cell counts(P>0.05).Conclusion:FGL2 protein is involved in occurrence and development of GIST,which expression level is partly pre-dictive of the malignant potential of GIST.FGL2 protein may participate in occurrence and development of GIST by regulating tumor microenvironment.
