Efficacy of Kunxian capsule in treating patients with lupus nephritis:A network Meta-analysis
10.3969/j.issn.1000-484X.2024.04.011
- VernacularTitle:昆仙胶囊相关方案治疗狼疮肾炎的有效性:网状Meta分析
- Author:
Zifeng LI
1
;
Yuling FAN
;
Wen YI
;
Xiaoqiang HOU
;
Long YIN
;
Caiyun CHANG
Author Information
1. 三峡大学第一临床医学院,宜昌市中心人民医院中医科,宜昌 443000
- Keywords:
Kunxian capsule;
Lupus nephritis;
Efficacy;
Meta-analysis
- From:
Chinese Journal of Immunology
2024;40(4):736-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the effectiveness of Kunxian capsule related regimens for patients with lupus nephritis(LN)in order to provide a reference basis for treatment strategies for LN patients.Methods:The computer searched the rele-vant studies of Kunxian capsule in PubMed,Web of Science,Cochrane Library,CBM,CNKI,Wanfang and VIP databases on the treatment of LN,the limited time for the establishment of the database is April 6,2022,and used R 4.0.2 software and Revman 5.3 software for Meta-analysis.Results:Four RCTs with 1 cohort study including 310 patients were finally included.The results of the Me-ta-analysis showed that:In terms of 24 h urinary protein and SLEDAI score,Glucocorticoid+Cyclophosphamide+Kunxian capsule achieved the best result after treatment;in terms of Scr,IgE,and IgG,the levels of each index were significantly lower in Glucocorti-coid+Cyclophosphamide+Kunxian capsules than in Glucocorticoid+Cyclophosphamide(P<0.05).Conclusion:The 5 regimens may work best as Glucocorticoids+Cyclophosphamide+Kunxian capsules in terms of clinical efficacy in treating LN patients.Because of the quality and quantity limitations of the included studies,more high-quality studies are needed for validation.
