Clinical research progress on intermittent fasting for weight loss in overweight and obesity

VernacularTitle:间歇性禁食用于超重或肥胖人群减重的临床研究进展
Author: Junren KANG ¹ ; Yunlong LI ; Yuanyuan BAO ; Kang YU
Author Information

1. 中国医学科学院　北京协和医学院　北京协和医院临床营养科，北京　100730
Keywords: Intermittent fasting; Obesity; Weight loss
From: Chinese Journal of Clinical Nutrition 2024;32(5):314-320
CountryChina
Language:Chinese
Abstract: Intermittent fasting (IF) is a common intensive nutrition and lifestyle intervention strategy for overweight and obesity. Common regimens in clinical studies consist of time-restricted feeding, alternate-day fasting and 5:2 diet. The mechanisms of IF in weight loss and metabolic health are complex. IF with rational design and regular follow-up has been shown to achieve weight reduction and improve insulin resistance and metabolic health in the population with overweight and obesity. IF has been widely used in many long-term follow-up and large sample studies without major complications. The lean body mass also showed a decrease following weight loss achieved through intermittent fasting intervention, but the ratio of lean body mass to body weight increased when adjusted for changes in weight. This review looks at the progress of clinical researches on common intermittent fasting regimens, in the aim to inform clinical practice.