Impact of soy protein and whey protein on body composition in hospitalized lung cancer patients with cancer-related sarcopenia
10.3760/cma.j.cn115822-20240829-00153
- VernacularTitle:大豆蛋白和乳清蛋白对肺癌相关肌少症住院患者人体成分的影响
- Author:
Yu ZHANG
1
;
Shijia WANG
;
Xiaoyan LIU
;
Yang DU
;
Kang YU
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院临床营养科，北京 100730
- Keywords:
Lung cancer;
Cancer-related sarcopenia;
Soy protein;
Whey protein
- From:
Chinese Journal of Clinical Nutrition
2024;32(5):270-278
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study aims to assess the effects of soy and whey protein on body composition and muscle function in hospitalized lung cancer patients with cancer-related sarcopenia.Methods:Paired comparison method was adopted for data collected before and after intervention. All enrolled non-small cell lung cancer patients with cancer-related sarcopenia were assigned to either the soy protein (30 g/d) or the whey protein (30 g/d) group to receive the 12-week intervention. Changes in muscle mass (MM) and muscle function before and after intervention were observed to assess intra-group and inter-group differences.Results:The study included 48 patients, 32 of whom completed the intervention and follow-up (16 from the whey protein group and 16 from the soy protein group). After 12 weeks of intervention with whey protein, significant increases were observed in trunk muscle mass (TMM, P=0.014) and TMM adjusted for height (TMM/Ht 2, P=0.011). After 12 weeks of intervention with soy protein, significant increases were noted in appendicular muscle mass (AMM, P=0.049), AMM adjusted for body mass index (AMM/BMI, P=0.044), fat free mass (FFM, P=0.041), and MM ( P=0.038). After adjustment using generalized estimating equations, only TMM/Ht 2 ( P=0.049) showed a significant increase in the whey protein group, while TMM ( P=0.040) and TMM/Ht 2 ( P=0.005) significantly increased in the soy protein group. Despite that all MM-related indices increased in both groups, there were no significant inter-group differences after adjusted by covariate analysis. Conclusions:Interventions with soy protein and whey protein can help maintain and improve muscle mass and muscle function in patients with lung cancer-related sarcopenia. Soy protein and whey protein may have comparable benefits in patients with lung cancer-related sarcopenia.
