The investigation on body composition in patients with active ulcerative colitis and its correlation with clinical outcome
10.3760/cma.j.cn115822-20240826-00151
- VernacularTitle:活动期溃疡性结肠炎患者体成分变化特点及其与临床结局的相关性探究
- Author:
Wei WEI
1
;
Pengguang YAN
;
Kang YU
;
Mengmeng ZHANG
;
Pengju LIU
;
Chunwei LI
;
Peipei CHEN
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院临床营养科，北京 100730
- Keywords:
Ulcerative colitis;
Muscle mass;
Phase angle;
Clinical outcome
- From:
Chinese Journal of Clinical Nutrition
2024;32(5):261-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the body composition of ulcerative colitis (UC) patients by bioelectrical impedance analysis (BIA) and explore the correlation between body composition indices and disease activity, laboratory indices, and readmission.Methods:Patients with active UC hospitalized in the Department of Gastroenterology of Peking Union Medical College Hospital were enrolled continuously, and age and sex ratio-matched healthy volunteers were recruited through recruitment posters. Body composition was measured via BIA. Appendicular skeletal muscle index (ASMI) and trunk skeletal muscle index (TSMI) were calculated and adjusted for height (m 2). Muscle function was evaluated via handgrip strength. Moreover, patients were followed up after discharge and the readmissions due to recurrence or aggravation of UC were recorded. Results:This study enrolled 62 UC patients and 38 healthy volunteers. TSMI decreased significantly ( P<0.001) while ASMI showed no significant difference in male patients compared with healthy controls. ASMI ( P<0.001) and TSMI ( P=0.002) in female patients were significantly lower than those in healthy controls. Compared with patients with normal TSMI, a larger proportion of patients with low TSMI tended to show severe disease activity ( P=0.075), while no such trend was observed in patients with low ASMI. Handgrip strength and phase angle were significantly positively correlated with ALB in UC patients ( P<0.05). The proportion of patients with readmission was significantly higher in the low phase angle group than that in the normal phase angle group (58.3% vs. 22.0%, P=0.040). Conclusions:There were abnormal body composition and gender differences in UC patients. TSMI correlated better with clinical characteristics than ASMI in UC patients. Low phase angle might be predictive for readmission in UC patients.
