The predictive performance of triglyceride and triglyceride-glucose index in the first trimester for gestational diabetes mellitus: a prospective cohort study
10.3760/cma.j.cn115822-20240127-00019
- VernacularTitle:前瞻性队列研究：孕早期甘油三酯及甘油三酯-葡萄糖指数对妊娠糖尿病的预测能力
- Author:
Yanbei DUO
1
;
Junxiang GAO
;
Shuoning SONG
;
Yuting GAO
;
Yong FU
;
Yingyue DONG
;
Tao YUAN
;
Weigang ZHAO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科 国家卫生健康委员会内分泌重点实验室，北京100730
- Keywords:
Gestational diabetes mellitus;
Triglyceride;
Triglyceride glucose index;
Early prediction
- From:
Chinese Journal of Clinical Nutrition
2024;32(2):90-97
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the predictive performance of triglyceride and triglyceride glucose (TyG) index in the first trimester for the onset of gestational diabetes mellitus (GDM).Methods:Pregnant women who visited Beijing Chaoyang Maternal and Child Health Care Hospital and Beijing Haidian Maternal and Child Health Care Hospital from 2019 to 2022 were prospectively included. Concurrently, 78 healthy non-pregnant women who visited the Department of Endocrinology of Peking Union Medical College Hospital were included. The clinical characteristics and laboratory biomarkers including fasting blood glucose and blood lipid profiles were collected at the first visit in early pregnancy. Oral glucose tolerance test (OGTT) was performed at 24-28 weeks of gestation for GDM screening. Multivariate Logistic regression analysis was used to determine the association between biomarkers in early pregnancy and the risk of GDM. The receiver operating characteristic curve was used to evaluate the predictive performance and to identify the optimal cut-off value of triglyceride and TyG index in the first trimester for the risk of GDM.Results:A total of 1 677 pregnant women were included in this study, and the prevalence of GDM in our cohort was 19.6%. Compared with women who did not develop GDM, women with GDM showed an older maternal age, higher pre-pregnancy body mass index, and increased levels of laboratory biomarkers including fasting blood glucose, fasting insulin, total cholesterol, triglyceride, low-density lipoprotein cholesterol, TyG index, and Homeostasis Model Assessment of Insulin Resistance ( P<0.001). Logistic regression analysis showed that both triglyceride and TyG index in the first trimester were independent risk factors for GDM. The optimal cut-off values of triglyceride and TyG index for predicting the risk of GDM were 0.93 mmol/L and 8.10, respectively. The predictive performance can be further improved if maternal age and pre-pregnancy BMI are included. Conclusion:Triglyceride and TyG index in early pregnancy are closely associated with the risk of GDM, and can be used as early predictors of GDM.
