The characteristics of gut microbiota in patients with type 2 diabetes mellitus and concurrent nonalcoholic fatty liver disease
10.3760/cma.j.cn115822-20240204-00021
- VernacularTitle:2型糖尿病合并非酒精性脂肪性肝病患者肠道菌群的特征分析
- Author:
Yuting GAO
1
;
Tianyi ZHAO
;
Shixuan LIU
;
Na LV
;
Tao YUAN
;
Junxiang GAO
;
Baoli ZHU
;
Weigang ZHAO
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院内分泌科，国家卫生健康委员会内分泌重点实验室，北京 100730
- Keywords:
Type 2 diabetes mellitus;
Nonalcoholic fatty liver disease;
Gut microbiota
- From:
Chinese Journal of Clinical Nutrition
2024;32(2):80-89
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the characteristics of gut microbiota in patients with type 2 diabetes (T2DM) complicated by nonalcoholic fatty liver disease (NAFLD).Methods:A total of 74 patients first diagnosed with T2DM at the Endocrinology Department of Peking Union Medical College Hospital from April 2021 to October 2023 were included. Among them, 28 patients had concurrent NAFLD while 46 patients did not. Additionally, 51 healthy controls were matched (HC group). Clinical laboratory parameters were collected, and 16S rRNA sequencing with fecal samples was conducted to compare the differences in gut microbiota across the groups.Results:Compared to the group with T2DM, patients with concurrent T2DM and NAFLD were younger, had higher level of insulin resistance as assessed by the homeostatic model assessment of insulin resistance, higher body mass index (BMI), and higher triglyceride levels. There was no difference in α-diversity across the three groups ( P>0.05), while there was a significant difference in β-diversity ( P=0.03). The Eubacterium coprostanoligenes, Fusicatenibacter, Parasutterella and Tyzzerella 3 were enriched in the group with concurrent T2DM and NAFLD as shown by the relative abundance, while the relative abundance of Flavonifractor was decreased in this group. Tyzzerella 3 abundance was positively correlated with triglyceride and albumin levels and negatively correlated with high-density lipoprotein cholesterol (HDL-C) levels. Conclusion:Patients with T2DM complicated by NAFLD exhibit dysbiosis in gut microbiota composition and specific genera abundance, with Flavonifractor identified as a potential protective factor for T2DM complicated by NAFLD.
