Research progress on anti-glioma mechanism of natural sesquiter-pene lactones
10.12092/j.issn.1009-2501.2024.10.011
- VernacularTitle:天然倍半萜内酯类成分抗胶质瘤作用机制的研究进展
- Author:
Xiaoting YAN
1
;
Xinye WANG
;
Ming BAI
;
Guodong YAO
Author Information
1. 沈阳药科大学药学院,沈阳 110016,辽宁
- Keywords:
glioma;
sesquiterpene lactone;
mech-anism of action
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(10):1174-1184
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is a common primary intracra-nial tumor.Malignant glioma has a high mortality rate and an inferior prognosis.Despite various ther-apeutic interventions,the overall survival rate is still meager.Sesquiterpene lactone is a kind of natu-ral product containing α-methylene-γ-lactone,which has strong anti-tumor activity.In recent years,there have been many reports on the anti-gli-oma effect of sesquiterpene lactone compounds,such as ACT001,which is a structural modification of sesquiterpene lactone(Parthenolide)and has en-tered the clinical trial stage as a potential antican-cer drug.This paper reviews the activity and mecha-nism of sesquiterpene lactones with anti-glioma ef-fects,which have been studied in recent.years.
