Comparison of remazolam and propofol on the recovery of psycho-motor function after painless gastrointestinal endoscopy
10.12092/j.issn.1009-2501.2024.10.010
- VernacularTitle:瑞马唑仑与丙泊酚用于无痛胃肠镜检查后对精神运动功能恢复的影响
- Author:
Shuangyan HU
1
;
Junfeng HU
;
Linling MAO
;
Yuhong ZHAO
;
Cheng XU
;
Kai QIU
;
Junfeng ZHONG
Author Information
1. 绍兴市人民医院麻醉科,绍兴市人民医院疼痛科,绍兴 312000,浙江
- Keywords:
remiazolam;
alfentanil;
propofol;
gas-trointestinal endoscopy;
psychomotor function
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(10):1168-1173
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To compare the recovery of psy-chomotor function after intravenous anesthesia with remazolam or propofol compound alfentanil in patients undergoing painless gastrointestinal en-doscopy.METHODS:78 patients undergoing pain-less gastrointestinal endoscopy were randomly di-vided into group RA and group PA.Remiazolam or propofol combined with alfentanil were given intra-venously in group RA or group PA.The blood pres-sure,heart rate,respiratory rate and saturation of puls oxygen were recorded before procdure(T1),during checking(T2),awaking from anaesthesia(T3)and at discharging from PACU(T4).Psychomo-tor function,as measured by the Trieger's dot test(TDT)and digit symbol substitution test(DSST),were evaluated before anesthesia(T1),at discharg-ing from PACU(T4),1 h(T5)and 2 h(T6)after checking.RESULTS:From assessment of the TDT,number of dots missed(NDM),maximum distance of dots missed(MDDM)and average distance of dots missed(ADDM)at T4,T5 were significantly lower than those at T1 in two groups.The comple-tion rates and accuracy rates of DSST at T4,T5 were significantly lower than those at T1.Results of TDT and DSST at T6 were not significantly differ-ent to those at T1.The results of NDT,MDDM and ADDM at T4,T5 in group RA were significantly low-er than those in group PA.The completion rates and accuracy rates of DSST at T4,T5 in group RA increased significantly compared with group PA.Compared to group PA,the incidence of hypoten-sion was significantly lower in group RA.There was no significant difference in the incidence of respira-tory depression between the two groups.CONCLU-SION:Psychomotor function was fully recovered 2 h after surgery when remazolam compound alfent-anil was used for painless gastrointestinal endosco-py.Compared with propofol,psychomotor function recovery in the remazolam group was faster and there were fewer adverse effects after surgery in group RA.
