Analysis of clinical characteristics and influencing factors of meropen-em concentration in patients with CNS infection
10.12092/j.issn.1009-2501.2024.10.007
- VernacularTitle:中枢性神经系统感染患者美罗培南血药浓度达标情况及影响因素分析
- Author:
Ruhua WEI
1
;
Wen CAO
;
Yating LU
;
Mingwei MENG
;
Juman LI
;
Yane QIN
;
Xiaobu LAN
;
Kai MO
Author Information
1. 广西医科大学第五附属医院/南宁市第一人民医院药学部,南宁 530022,广西
- Keywords:
CNS infection;
meropenem;
TDM
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(10):1146-1151
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To analyze the compliance rate and possible influencing factors for blood concen-tration of meropenem in patients with central ner-vous system(CNS)infections,and to provide basis for optimizing the administration of meropenem in the patients.METHODS:A retrospective analysis was performed in patients who were treated with meropenem and monitored the concentration(Cmin)from January 2021 to December 2022.The basic clinical data of the patients were recorded,and the achievement of meropenem blood concentration was counted.Univariate and binary logistic regres-sion analysis were used to analyze the influencing factors for the e substandard steady-state blood trough concentration of meropenem.The ROC curve was drawn to predict the clinical characteris-tics.RESULTS:Forty-five cases were included.The median Cmin of meropenem was 4.14(0.82,16.29)mg/L,and 51.11％reached the target range with 4 mg/L.Binary logistic regression analysis showed that serum creatinine value and using mannitol were risk factors for the substandard steady-state blood trough concentration of meropenem(P＜0.05).When serum creatinine value was less than 84 μmol/L,the area under the ROC curve was the largest(0.916),the sensitivity was 0.783,the speci-ficity was 0.955,and the Youden index was 0.738.CONCLUSION:The Cmin compliance rate of merope-nem blood concentration in patients with CNS in-fection is low,especially in patients with hyperfunc-tion of kidney and those who using mannitol.It is necessary to conduct drug concentration monitor-ing to optimize the administration of meropenem in patients with CNS infection.
