Research progress of molecular docking in screening anti-cervical cancer drugs
10.12092/j.issn.1009-2501.2024.08.018
- VernacularTitle:分子对接在筛选抗宫颈癌药物中的研究进展
- Author:
Dan WANG
1
;
Wenyan ZHANG
;
Renjie LUO
;
Yuanjing CHEN
;
Xue HAN
;
Bo QU
;
Shifang FENG
;
Xiazi NIE
;
Huiling LIU
Author Information
1. 甘肃中医药大学第一临床医学院
- Keywords:
cervical cancer;
molecular docking;
virtual screening;
target protein;
action mechanism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(8):955-960
- CountryChina
- Language:Chinese
-
Abstract:
Cervical cancer is one of the most common gynecological malignant tumors,the five-year survival rate decreased significantly in the case of lymph node metastasis and distant metasta-sis,so the development of new anti-cervical cancer drugs is of great significance for the treatment of cervical cancer.Molecular docking technology is one of the most commonly used research methods in computer aided drug design,which is widely used in screening the effective components of drugs,finding the targets of drugs acting on tumors and exploring the mechanism of antineoplastic drugs.This paper reviews the molecular docking technology in the screening of anti-cervical cancer drugs,the determination of anti-tumor targets and the mechanism of anti-cervical cancer,in order to provide more sufficient theoretical basis for the screening of anti-cervical cancer drugs and new drug research and development.
