Research progress of miRNA in ulcerative colitis
10.12092/j.issn.1009-2501.2024.08.009
- VernacularTitle:miRNA在溃疡性结肠炎中的研究进展
- Author:
Xuan LIU
1
;
Cuijuan FENG
;
Yiqiang WANG
;
Fang LI
Author Information
1. 甘肃卫生职业学院,兰州 730000,甘肃
- Keywords:
ulcerative colitis;
microRNA(miRNA);
pathogenesis;
biomarkers;
treatment strategy;
re-search progress
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(8):917-929
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is a chronic im-mune-mediated disease characterized by diffuse mucosal inflammation and clinical symptoms of ab-dominal pain,diarrhea,mucopurulent bloody stool and tenesmus.Due to its complex etiology,difficult treatment and poor prognosis,UC has been listed as one of the modern refractory diseases by the World Health Organization.MicroRNAs(microR-NAs)regulate various biological processes such as cell growth,differentiation,and development by regulating gene expression.Studies have shown that miRNA is involved in the pathogenesis of UC through various pathways such as intestinal muco-sal barrier homeostasis disorder,intestinal flora im-balance and excessive differentiation of immune cells,and is expected to become a new target for clinical treatment of UC.In order to better under-stand the role of miRNA in the pathogenesis of UC and provide new research directions for the treat-ment of UC,this article reviews the correlation be-tween miRNA and the pathogenesis of UC,the po-tential of miRNA as a biomarker of UC,and the treatment strategies of miRNA in UC in recent years.
