Research progress on material basis and mechanism of Hedyotis Dif-fusa-Scutellaria Barbata Herb Pair in the treatment of gastric cancer
10.12092/j.issn.1009-2501.2024.07.014
- VernacularTitle:白花蛇舌草-半枝莲药对治疗胃癌的物质基础和作用机制研究进展
- Author:
Xiaowei ZHANG
1
;
Nan WANG
;
Mengge DAI
;
Ruijuan LIU
;
Ting MA
Author Information
1. 郑州大学药学院,郑州 450001,河南
- Keywords:
Hedyotis diffusa;
Scutellaria barbata;
drug pair;
gastric cancer;
pharmacological mecha-nism
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(7):831-840
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer is one of the most com-mon malignant tumors in the digestive system,which often occurs in middle-aged and elderly peo-ple.Traditional Chinese medicine recognizes gastric cancer as a kind of tumor characterized by fluid de-ficiency,heat accumulation and the growing bind-ing of toxins in the stomach.It is commonly treated with heat-clearing and detoxifying drugs in clinical practice.Hedyotis diffusa-Scutellaria barbata herb pair(HS)has the effects of clearing heat and detoxi-fying,promoting blood circulation,resolving car-buncle and expulsing boil,anti-inflammatory and analgesic,which are consistent with the etiology and pathogenesis of gastric cancer,therefore,it can be used for the treatment of gastric cancer.Modern pharmacological researches have con-firmed that HS can play an anti-gastric cancer role by inducing cell apoptosis,inhibiting cell prolifera-tion,inhibiting angiogenesis,improving immune mi-croenvironment and down-regulating telomerase activity.Herein,this review summarizes the active ingredients and related mechanism responsible for the anti-gastric cancer effect of HS,which will pro-vide the theoretical basis for its clinical use and the development of new drugs against gastric cancers.
