Analysis of clinical characteristics of tramadol induced hypoglycemia
10.12092/j.issn.1009-2501.2024.07.012
- VernacularTitle:曲马多诱导的低血糖的临床特征分析
- Author:
Wei LIU
1
;
Qin HE
;
Yiran HE
Author Information
1. 湖南中医药大学第一附属医院药学部,长沙 410007,湖南
- Keywords:
tramadol;
hypoglycemia;
analgesics;
opioid;
adverse drug reactions
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2024;29(7):819-825
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To investigate the clinical charac-teristics of tramadol-induced hypoglycemia.METH-ODS:Case reports of tramadol-induced hypoglyce-mia were collected by searching Chinese and Eng-lish data from the database establishment to April 28,2023.RESULTS:Twenty patients were included,with a median age of 50 years(4,88).Hypoglyce-mia occurred 1 h-23 d after tramadol administra-tion,with a median blood glucose of 2.25 mmol/L(0.22,3.3)and a median daily dose of 300 mg(1.53,14 000).The main clinical manifestations were unconscious(12 cases),multiple organ failure(7 cases),asystole and/or apnea(7 cases),seizures(4 cases),somnolence(3 cases)and sweating(3 cases).Tramadol concentrations were reported in 6 patients,with a median of 3.56 mg/L(0.47,9.4).Af-ter stopping tramadol in 20 patients and giving symptomatic supportive treatment,16 patients re-covered,1 patient had moderate brain dysfunction,and 3 patients died.CONCLUSION:Tramadol in-duced hypoglycemia can occur from 1 h to 23 d af-ter administration,and can be clinically manifested as autonomic nervous system symptoms and neu-rohypoglycemia symptoms,mainly neurohypoglyce-mia symptoms.After stopping tramadol,most pa-tients with hypoglycemia returned to normal,and severe patients can die.
